D-dimeer Recombinant antilichaam [3B6] (OAAV00099)

Fibrinogen alpha chain

Fib2; fibrinogen alpha chain; fibrinogen, A alpha polypeptide.

2243

P02671

NP_000499.1

Human

Human cross-linked D-Dimer.

3B6

Recombinant Monoclonal Antibody

Purified

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

PBS with 0.02% Proclin 300.

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

IgG3, kappa

Recognises epitopes that reside between amino acids 86 and 302 in the gamma-chain of fragment D chains of fibrinogen (Fragment D) and other cross-linked fibrin degradation products containing D-Dimer, but no reactivity with Fragment D or E, fibrinogen or fibrinogen degradation products.

FGA

Mouse

Fibrinogen alpha chain

FGA

NM_000508.4