D-Mannitol, M100 (GMP Like)

D-Mannitol, M100 (GMP Like) (Mannitol, M100 (GMP Like) ) is the GMP Like class D-Mannitol that can be used as pharmaceutical excipients. D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β3-adrenergic receptor (β3-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells[1][2][3][4][5][6][7].

69-65-8

Mannitol, M100 (GMP Like) ; Mannite, M100 (GMP Like)

12352211

Adrenergic Receptor; Apoptosis; Endogenous Metabolite; PGC-1α; PKA

Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad

Cancer; Metabolic Disease; Cardiovascular Disease

OC[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

C6H14O6

182.17

[1]Tan, K., et al., The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J Biol Chem, 2009. 284 (52) : p. 36670-9. |[2]Nishiyama, A., et al., Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats. J Nutr Sci Vitaminol (Tokyo), 2009. 55 (3) : p. 242-51.|[3]Hanieh, H. and E. Sakaguchi, Effect of D-mannitol on feed digestion and cecotrophic system in rabbits. Anim Sci J, 2009. 80 (2) : p. 157-62.|[4]Kaufmann AM, et al. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. J Neurosurg. 1992;77 (4) :584-589. |[5]Xiao J, et al. Sakaguchi E. Mannitol improves absorption and retention of calcium and magnesium in growing rats. Nutrition. 2013;29 (1) :325-331.|[6]Paczynski RP, et al. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction. Stroke. 1997;28 (7) :1437-1444.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N0378BGL/

GMP Small Molecules

No Development Reported