D-Mannoheptulose-13C7

D-Mannoheptulose-13C7 is the 13C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources[1][2][3][4].

12352005

Hexokinase; Isotope-Labeled Compounds

Metabolic Enzyme/Protease; Others

Cancer; Metabolic Disease

O[13C@@H]1[13C@H](O[13C]([13CH2]O)([13C@H]([13C@H]1O)O)O)[13CH2]O

13C7H14O7

217.13

[1]D-mannoheptulose and perseitol in ‘Hass’ avocado: Metabolism in seed and mesocarp tissue. South African Journal of Botany. 2012 Mar; 79:159-165.|[2]Courtois P, et al. D-mannoheptulose phosphorylation by hexokinase isoenzymes. Int J Mol Med. 2001 Apr;7 (4) :359-63.|[3]Frenkel G, et al. Metabolic effects of insulin blockade by D-mannoheptulose in the sand rat (Psammomys obesus) and the rat. Gen Comp Endocrinol. 1972 Oct;19 (2) :341-4.|[4]Al-Ziaydi, A.G. Evaluation of D-Mannoheptulose and Doxorubicin as Potential Therapeutic Agents for Breast Cancer by Targeting Glycolysis and Inducing Apoptosis. Ind J Clin Biochem (2024) .

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W767186/

Isotope-Labeled Compounds

No Development Reported