D-myo-Inositol-1,4,5,6-tetrafosfaat

D-myo-Inositol-1,4,5,6-tetraphosphate (D-Ins (1,4,5,6) P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. It almost completely inhibits calcium-activated chloride channels at a concentration of 8-10 μM [1].

121010-58-0

Inositol 1,4,5,6-tetraphosphate; D-Ins (1,4,5,6) P4

12352211

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolism-protein/nucleotide metabolism

Metabolic Disease

O=P(O)(O)O[C@@H]1[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@@H](O)[C@H]1O

C6H16O18P4

500.08

[1]Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, Shears SB. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem. 1999 Jul 2;274 (27) :18973-80.|[2]Xie W, Kaetzel MA, Bruzik KS, Dedman JR, Shears SB, Nelson DJ. Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells. J Biol Chem. 1996 Jun 14;271 (24) :14092-7.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W703190/

Natural Products

No Development Reported