[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat

[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects[1].

12352209

Histamine Receptor; Neuropeptide Y Receptor

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Cardiovascular Disease

OC(C=C1)=CC=C1C[C@@H](N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H]([C@@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O

C61H99N19O15

1338.56

[1]Roscoe AK, et al. Hypotensive effects of [D-Tyr27,36, D-Thr32]Neuropeptide Y (27-36) . Peptides. 1995;16 (8) :1411-5.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11411/

Peptides

No Development Reported