D15

D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research[1].

251939-41-0

Dynamin II (828–842)

12352209

IGluR

Membrane Transporter/Ion Channel; Neuronal Signaling

Neurological Disease

O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]6N(CCC6)C([C@@H]7CCCN7)=O

C69H111N23O19

1566.76

[1]Wan Y, et al. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci. 2011 Nov 16;31 (46) :16685-91.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P1386/

Peptides

Launched

AMPA Receptor