D2A21 (TFA)

D2A21 TFA is an antimicrobial peptide with significant antimicrobial activity against Pseudomonas and bactericidal effect on burn scabs. D2A21 TFA has antitumor activity and can be used in prostate cancer research[1][2].

12352209

Bacterial

Anti-infection

Cancer; Infection

95.35

OC([C@H](CC1=CC=CC=C1)NC([C@H](C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC4=CC=CC=C4)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC5=CC=CC=C5)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C)NC([C@@H](N)CC6=CC=CC=C6)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]

C144H212N32O24.xC2HF3O2

2775.42 (free base)

[1]Chalekson CP, et al. Improvement in burn wound infection and survival with antimicrobial peptide D2A21 (Demegel) . Plast Reconstr Surg. 2002 Apr 1;109 (4) :1338-43.|[2]Arlotti JA, et al. Efficacy of a synthetic lytic peptide in the treatment of prostate cancer. Urol Oncol. 2001 May;6 (3) :97-102.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P11211A/D2A21-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported