DAAM1 Antilichaam

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl) -Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.

23002

Q9Y4D1

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 769-1068 of human DAAM1 (NP_001257449.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction, Stem Cell

Affinity purification

U-87MG

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 123kDa

IgG

WB: 1:500 - 1:2000

DAAM1

HepG2

Mouse heart

Mouse brain

Mouse liver

Rat heart

Dishevelled associated activator of morphogenesis 1

Homo sapiens

DAAM1, FLJ41657, KIAA0666

WB

Liquid