DABCYL-RAGGYIFS- (E-EDANS) -NH2

DABCYL-RAGGYIFS- (E-EDANS) -NH2, an octapeptide, is a FRET-based substrate peptide of CHIKV nsP2protease with highly sensitivity. DABCYL-RAGGYIFS- (E-EDANS) -NH2 can be cleaved by the active CHIKV nsP2protease, separating fluorophore and quencher and resulting in an increase of fluorescence signal. DABCYL-RAGGYIFS- (E-EDANS) -NH2 can used for the determination of CHIKV nsP2protease activity[1].

12352209

CHIKV; Virus Protease

Anti-infection

Infection

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(NCC(NCC(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CO)C(N[C@@H](CCC(NCCNC3=CC=CC4=C(S(=O)(O)=O)C=CC=C34)=O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)C5=CC=C(/N=N/C6=CC=C(C=C6)N(C)C)C=C5

C72H92N18O16S

1497.68

[1]Saha A, et al. Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus. Sci Rep. 2018 Jul 17;8 (1) :10831.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11302/

Peptides

No Development Reported