Dabigatran etexilaat-d11

Dabigatran etexilate-d11 (BIBR 1048-d11) is the deuterium labeled Dabigatran etexilate. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran (a direct inhibitor of thrombin). Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1].

2469006-94-6

BIBR 1048-d11

12352005

Isotope-Labeled Compounds; Thrombin

Metabolic Enzyme/Protease; Others

Cardiovascular Disease

O=C(N(C1=NC=CC=C1)CCC(OCC)=O)C2=CC=C3C(N=C(N3C)CNC4=CC=C(C=C4)C(NC(OCC([2H])(C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])[2H])=O)=N)=C2

C34H30D11N7O5

638.80

[1]Blair HA, Keating GM. Dabigatran Etexilate: A Review in Nonvalvular Atrial Fibrillation. Drugs. 2017;77 (3) :331-344. |[2]Wienen W, et al. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98 (1) :155-62.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W705434/

Isotope-Labeled Compounds

No Development Reported