Dabrafenib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively) .1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
Unconjugated
Off-white solid
-20°C
Beschrijving
Dabrafenib Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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