Dacomitinib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
1110813-31-4
PF299804, PF299
C17028-10mg
EGFR
Protein Tyrosine Kinase
COC1=C (C=C2C (=C1) N=CN=C2NC3=CC (=C (C=C3) F) Cl) NC (=O) C=CCN4CCCCC4
C24H25ClFN5O2
Dacomitinib is a potent, irreversible pan-ErbB inhibitor, mostly to EGFR with IC50 of 6 nM in a cell-free assay. Dacomitinib inhibits ERBB2 and ERBB4 with IC50 of 45.7 nM and 73.7 nM, respectively. Dacomitinib is effective against NSCLCs with EGFR or ERBB2 mutations as well as those harboring the EGFR T790M mutation. Dacomitinib inhibits cell growth and induces apoptosis. Phase 2.
2 years -80 in solvent
Beschrijving
Dacomitinib Beschikbaar in 10 mg. Wordt geleverd met droogijs. Bestel eenvoudig online met snelle levering.
Specificaties
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