DAP-antilichaam

DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1) . DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51; under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2) .

1611

P51397

NP_004385

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy

DAP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (89%)

DAP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DAP antibody is human, mouse and rat reactive.

DAP

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Death-associated protein

Homo sapiens

Deiss LP, Feinstein E, Berissi H, et al. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 1995; 9:15-30.

Koren I, Reem E, and Kimchi A. DAP1, a novel substrate of mTOR, negatively regulates autophagy. Curr. Biol. 2010; 20:1093-8.

DAP Antibody: DAP1, Death-associated protein 1, DAP-1

ELISA, WB, IHC-P, IF

4758120

Liquid