DBCO-tag peptide P1

DBCO-tag peptide P1 is a cysteine-containing peptide tag. DBCO-tag peptide P1 selectively reacts with dibenzocyclooctyne (DBCO) to yield stable dibenzocyclooctenyl thioethers. DBCO-tag peptide P1 enables site-selective mEGFP labeling and antibody (such as Trastuzumab ) labelling without impairing the protein binding function. DBCO-tag peptide P1 can be used for ADC synthesis and mEGFP labeling research[1].

12352209

Biochemical Assay Reagents; Drug-Linker Conjugates for ADC

Antibody-drug Conjugate/ADC Related; Others

Others

O=C(N[C@@H](CS)C(N[C@@H](CC1=CC=C(C=C1)O)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](C(C)C)C(N[C@@H](CC5=CC=C(C=C5)O)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

C48H62N8O10S

943.12

[1]Zhang C, et al. Site-Selective Cysteine-Cyclooctyne Conjugation. Angew Chem Int Ed Engl. 2018 May 28;57 (22) :6459-6463.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11316/

Peptides

No Development Reported