DBI Antilichaam

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

1622

P07108

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human DBI (NP_001171513.1) .

Unconjugated

Primary Antibodies

Neuroscience, Obesity

Affinity purification

HT-29

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 11kDa

IgG

DBI

THP-1

MCF7

NCI-H460

A673

U-937

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)

Homo sapiens

DBI, ACBP, Acyl-CoA-binding protein, CCK-RP, Diazepam-binding inhibitor, ACBD1, GABA receptor modulator, EP, Endozepine

WB, IHC, IF

Liquid