DC-SIGN-antilichaam [8B6]

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

30835

Q9NNX6

Q9NNX6

Human

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

8B6

Unconjugated

Primary Antibodies

Infectious Disease

DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Cat. No. 1384 - Human Uterus Tissue Lysate

1 mg/mL

DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DC-SIGN monoclonal antibody can be stored at -20˚ C, stable for one year.

IgG1, k

CD209

Cat. No. 1369 - Human Lymph node Tissue Lysate

CD209 molecule

Homo sapiens

Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97.

Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001;75:4664-72.

Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.

Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.

DC-SIGN Antibody [8B6] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

ELISA, WB, IHC-P

46396012

Liquid