DC-SIGNR Recombinant antilichaam [16E7] (OAAV00097)

C-type lectin domain family 4 member M

CD209 antigen-like protein 1; CD209L; CD299; CD299 antigen; C-type lectin domain family 4 member M; DC-SIGN2; DCSIGNR; DC-SIGNR; DC-SIGN-related protein; dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; L-SIGN; mannose binding C-type lectin DC-SIGNR.

10332

Q9H2X3

NP_001138377.1

Human

CD299

This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.

160000000

Recombinant Monoclonal Antibody

Purified

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.

PBS with 0.02% Proclin 300.

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

IgG, kappa

Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.

CLEC4M

Rabbit

C-type lectin domain family 4 member M

CLEC4M

NM_001144905.1