DC260126
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
346692-04-4
C16004-25mg
GPR
GPCR & G Protein
CCCCC1=CC=C (C=C1) NS (=O) (=O) C2=CC=C (C=C2) F
C16H18FNO2S
DC260126, a small organic antagonist for GPR40 (FFAR1), dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50=6.28, 5.96, 7.07, 4.58 μM, respectively), reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells.
3 years -20°C powder
Beschrijving
DC260126 Beschikbaar in 25 mg. Bestel eenvoudig online met snelle levering.
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