DCAMKL1 Antilichaam / Doublecortin-achtige en CAM kinase-achtige 1 / DCLK1

This gene encodes a member of the protein kinase superfamily and the doublecortin family called Doublecortin-like and CAM kinase-like 1 (DCAMKL1) or Doublecortin-like kinase 1 (DCLK1) . The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity.

Western blot: 1:1000-1:5000

Q9JLM8

Human, Mouse

A portion of amino acids 690-720 from the human protein was used as the immunogen for this DCAMKL1 antibody.

WB

Antigen affinity

Antigen affinity purified

This DCAMKL1 antibody is available for research use only.

Aliquot the DCAMKL1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the DCAMKL1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Western blot testing of 1) human brain, 2) mouse brain, 3) rat brain and 4) TT cell lysate with DCAMKL1 antibody. Predicted molecular weight: ~82 kDa and ~47 kDa (multiple isoforms) .