DCK Antilichaam - middengebied: Biotine (ARP51774 P050-Biotine)

Deoxycytidine kinase

MGC117410, MGC138632

1633

P27707

NP_000779

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human DCK

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; EFHD2; CHRAC1; CHMP4A; CBX3; TYMS; THOP1; TALDO1; RBBP7; RANBP1; PTMS; IDH1; HSPE1; ADSS; TFEC; ELAVL1; RXRG; DCK; MED19; GOLM1; DDX19B

Biotin

Polyclonal Antibody

WB

Affinity Purified

DCK is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 93%; Dog: 86%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

30kDa

Iyidogan, P. (2008) Biochemistry 47 (16), 4711-4720

Wet Ice

260

DCK

DCK

Rabbit

Deoxycytidine kinase

NM_000788

QLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQD