DCLRE1C Antilichaam - N-terminaal gebied: Biotine (ARP51164_P050-Biotine)

DNA cross-link repair 1C

SCIDA, SNM1C, A-SCID, RS-SCID, DCLREC1C

64421

Q96SD1

NP_001029027

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human DCLRE1C

DCLRE1C is a nuclear protein that is involved in V (D) J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA) .This gene encodes a nuclear protein that is involved in V (D) J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA) .

XRCC5; PRKDC; RAD50; NBN; MRE11A; BRCA1; ATR; ATM; PSMD9; DDB2; DDB1; FBXW7; TP53BP1

Biotin

Polyclonal Antibody

WB

Affinity Purified

DCLRE1C is supported by BioGPS gene expression data to be expressed in HEK293T

0.5 mg/ml

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

78kDa

Bethke, L., (2008) J. Natl. Cancer Inst. 100 (4), 270-276

Wet Ice

692

DCLRE1C

DCLRE1C

Rabbit

Protein artemis

NM_001033855

SSFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRL