DCNP

DCNP binds to NPR-B/C receptor, activates cGMP signaling pathway, and regulates vascular function. dCNP exhibits anti-hypoxia property through downregulation of hypoxia-related genes expressions like HIF1α and HIF2α. dCNP inhibits the induction of tumor stroma and exhibits anti-fibrosis activity. dCNP upregulates CTLs, NK cells, and conventional type 1 dendritic cells in tumors, and activates immune responses[1].

12352209

Natriuretic Peptide Receptor (NPR)

GPCR/G Protein

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

95.79

DMSO : 50 mg/mL (ultrasonic)

O=C([C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CCCCN)N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NC1)=O)CC(C)C)=O)=O)CO)=O)CCSC)=O)CO)=O)=O)[C@H](CC)C)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)=O)CC2=CC=CC=C2)=O)CSSC[C@H](NC1=O)C(O)=O)=O)=O)CCCCN)=O)CO)=O)CC(C)C)=O)=O)=O)=O)=O)CCCCN)=O)CCCCN)=O)CCCCN

C141H248N38O36S3

3147.91

[1]Lu Z, et al., Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies. Sci Transl Med. 2024 Aug 21;16 (761) :eadn0904.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10869/dCNP-SDS-MedChemExpress.pdf

Peptides

No Development Reported