DCNP1 Antilichaam

The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1) . It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3) . DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4) .

140947

Q8TF63

NP_570900

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

DCNP1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

1 mg/mL

DCNP1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DCNP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DCNP1 antibody is human, mouse and rat reactive.

C5orf20

Chromosome 5 open reading frame 20

Homo sapiens

Masuda M, Senju S, Fujii Si S, et al. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. Biochem. Biophys. Res. Commun. 2002; 290:1022-9.

Willis-Owen SA, Shifman S, Copley RR, et al. DCNP1: a novel candidate gene for major depression. Mol. Psychiatry 2006; 11:121-2.

Bosker FJ, Hartman CA, Nolte IM, et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol. Psychiatry 2011; 16:516-32.

Zhou T, Wang S, Ren H, et al. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 2010; 133:3069-79.

DCNP1 Antibody: DCNP1, C5orf20, Dendritic cell nuclear protein 1

ELISA, WB, IHC-P, IF

18677770

Liquid