DcR3 Antilichaam

DcR3 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively, . Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

8771

O95407

AF104419

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

DcR3 Antibody is Ion exchange chromatography purified.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/ml

DcR3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DcR3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

33 kDa

IgG

TNFRSF6B

Cat. No. 10-501 - Human Heart Tissue Slide

Tumor necrosis factor receptor superfamily, member 6b, decoy

Homo sapiens

Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature 1998;396:699-703

Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem 1999;274:13733-6 (RD1299)

DcR3 Antibody: M68, TR6, DCR3, M68E, DJ583P15.1.1, UNQ186/PRO212, Tumor necrosis factor receptor superfamily member 6B, Decoy receptor 3, DcR3

ELISA, WB, IHC-P

4106877

Liquid