DCX Antilichaam

This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.

1641

O43602

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 92-441 of human DCX (NP_000546.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience

Affinity purification

Mouse brain

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 40kDa

IgG

WB: 1:500 - 1:2000

DCX

Doublecortin

Homo sapiens

Neuronal migration protein doublecortin, lissencephalin-X, lis-X, doublin, doublecortex, OTTHUMP00000216316, XLIS, SCLH, LISX, FLJ51296, DC, DBCN, RP5-914P14.1, doublecortin, DCX

WB

Liquid