DD-S067

DD-S067 is an antibacterial peptide. DD-S067 exhibits multiple antibacterial mechanisms, including disrupting both the outer and inner bacterial membranes, and inducing ROS that trigger lipid peroxidation. DD-S067 inhibits the electron transport chain. DD-S067 demonstrates potent antibacterial activity, achieving a GM value of 4.1 μM against 27 MDR bacteria. DD-S067 exhibits significant protective effects in a CRAB-induced septic shock mouse model[1].

12352209

Bacterial; Reactive Oxygen Species (ROS)

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Infection

O=C(N[C@H](CC1=CNC2=CC=CC=C12)C(N[C@H](CCCNC(N)=N)C(N[C@H](C(C)C)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(N[C@H](C)C(N[C@H](CC3=CC=C(C=C3)O)C(N[C@H](CC(C)C)C(N[C@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](CCCCN)N

C70H118N24O12

1487.84

[1]Lee JK, et al. A Novel Peptide Antibiotic Targeting Gram-Negative Infections Designed from Mycobacterium tuberculosis Adenylate Kinase. J Med Chem. 2025 Sep 25;68 (18) :19303-19330.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11475/

Peptides

No Development Reported