DDB2 Antilichaam - C-terminalgebied: FITC (ARP60163 P050-FITC)

Damage-specific DNA binding protein 2, 48kDa

XPE, DDBB, UV-DDB2

1643

Q92466

NP_000098

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the C terminal region of human DDB2

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities.

CUL4A; CUL4B; XPC; PARP1; UBC; SUMO1; SMEK1; COPG1; POP1; PSMB4; PSMB1; PSMA5; SEPT2; ARCN1; SUMO2; DDB1; USP24; USP53; RFWD2; COPS4; COPS6; COPS2; COPS3; XPA; TOP1; GRK5; EP300; COPS7A; COPS5; COPS8; RBX1; GPS1; E2F1; DDB2; CUL5; NEDD8; DCLRE1C; vpr; ERC

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 79%; Rabbit: 93%; Rat: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

48kDa

Wet Ice

427

DDB2

DDB2

Rabbit

DNA damage-binding protein 2

NM_000107

IVVGRYPDPNFKSCTPYELRTIDVFDGNSGKMMCQLYDPESSGISSLNEF