DDB2 (NM 000107) Humaan Recombinant eiwit

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Purified recombinant protein of Human damage-specific DNA binding protein 2, 48kDa (DDB2), Met1-Leu250, with N-terminal His tag, expressed in E. coli, 50ug

DDBB; UV-DDB2; XPE

1643

Q92466

NM_000107

11p11.2

E. coli

N-His

Nucleotide excision repair, p53 signaling pathway, Ubiquitin mediated proteolysis

Nucleotide excision repair, p53 signaling pathway, Ubiquitin mediated proteolysis

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0.

Druggable Genome

27.7 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

DDB2

Human

NP_000098

https://www.ncbi.nlm.nih.gov/gene/1643

https://www.uniprot.org/uniprot/Q92466

https://www.ncbi.nlm.nih.gov/nuccore/NM_000107

https://www.ncbi.nlm.nih.gov/nuccore/NP_000098