DDC Antilichaam

DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1) . It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2) . It can form a homodimer and is expressed in the central nervous system (2) . DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4) . Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4) .

1644

P20711

NP_000781

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

DDC Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (92%), Guinea pig: (77%), Pig: (77%)

DDC Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DDC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DDC antibody is human, mouse and rat reactive.

DDC

Cat. No. 10-101 - Human Lung Tissue Slide

Dopa decarboxylase (aromatic L-amino acid decarboxylase)

Homo sapiens

Berry MD, Juorio AV, Li XM, et al. Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem. Res. 1996; 21:1075-87.

Sumi-Ichinose C, Ichinose H, Takahashi E, et al. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and Serotonin biosynthesis. Biochemistry 1992; 31:2229-38.

Haycock JW, Becker L, Ang L, et al. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J. Neurochem. 2003; 87:574-85.

Chang YT, Sharma R, Marsh JL, et al. Levodopa-responsive aromatic L-amino acid decarboxylase deficiency. Ann. Neurol. 2004; 55:435-8.

DDC Antibody : AADC, AADC, Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase

ELISA, WB, IHC-P, IF

4503281

Liquid