DDR1 (fosfo-Tyr513) Antilichaam

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI) .

780

Q08345

NP_001189450.1

Human, Mouse, Rat

DDR1 (phospho Tyr513) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 513 (K-K-Y (p) -V-R) derived from Human DDR1 .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

110 kDa

IgG

The antibody detects endogenous levels of DDR1 only when phosphorylated at tyrosine 513.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

DDR1

Discoidin domain receptor tyrosine kinase 1

Homo sapiens

Di Marco E., J. Biol. Chem. 268:24290-24295 (1993) .

Johnson J.D., Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681 (1993) .

Laval S., Cell Growth Differ. 5:1173-1183 (1994) .

CAK, RTK6, TRKE, EDDR1

WB, IHC

729008

Liquid