DDR2 Antilichaam

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.

4921

Q16832

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 290-400 of human DDR2 (NP_001014796.1) .

Unconjugated

Primary Antibodies

Immunology, Neuroscience, Signal Transduction

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 110kDa

IgG

WB: 1:500 - 1:2000

DDR2

A375

HT-1080

Mouse lung

Mouse heart

Mouse kidney

Discoidin domain receptor tyrosine kinase 2

Homo sapiens

DDR2, CD167b antigen, Discoidin domain receptor 2, Hydroxyaryl-protein kinase, MIG20a, Tyrosine-protein kinase TYRO10, NTRKR3, TYRO10, Tyrosylprotein kinase

WB

Liquid