DDX60 Antilichaam

DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.

55601

Q8IY21

NP_060101

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

DDX60 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

DDX60 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DDX60 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of DDX60 are known to exist; this antibody will detect all three isoforms.

DDX60

Cat. No. 17-208 - A-20 Cell Slide

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

Homo sapiens

Miyashita M, Oshiumi H, Matsumoto M, et al. DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling. Mol. Cell. Biol. 2011; 31:3802-19.

DDX60 Antibody: Probable ATP-dependent RNA helicase DDX60, DEAD box protein 60

ELISA, WB, IF

222831595

Liquid