De heer1.1[S4Dap, C16Pen]

Mr1.1[S4Dap, C16Pen] is a highly active and selective nAChR (human α9α10 nAChR IC50 = 4.0 nM, rat α9α10 nAChR IC50 = 2.7 nM) inhibitor. Mr1.1[S4Dap, C16Pen] can significantly relieve pain and has significant stability. Mr1.1[S4Dap, C16Pen] can be used for the study of neuropathic pain[1].

12352209

NAChR

Membrane Transporter/Ion Channel; Neuronal Signaling

Neurological Disease

O=C([C@@H](N)CC1=CNC=N1)NCC(N[C@H](C(N[C@H](C(NC[C@H](C(N[C@H](C(N2[C@H](C(N[C@H]3C)=O)CCC2)=O)CC4=CNC=N4)=O)CSSC(C)(C)[C@@H](C(N)=O)NC5=O)=O)CN)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H]5[C@H](CC)C)=O)CC(O)=O)=O)CCC6)=O)CC(N)=O)=O)CC(N)=O)=O)C(C)C)=O)CO)=O)NC3=O)=O

C71H109N25O22S4

1793.04

[1]Li T, et al. Development of an Intravenously Stable Disulfide-Rich Peptide for the Treatment of Chemotherapy-Induced Neuropathic Pain. J Med Chem. 2024 Nov 14;67 (21) :18741-18752.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P11249/

Peptides

No Development Reported