DEDAF Antilichaam

DEDAF Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor. DEDAF is identical to the transcriptional repressor RYBP. DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

23429

Q8N488

AF179286

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis

DEDAF Antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 - A549 Cell Lysate

1 mg/mL

DEDAF Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DEDAF antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

32 kDa

IgG

RYBP

Cat. No. 1211 - HepG2 Cell Lysate

Cat. No. 1404 - Mouse Liver Tissue Lysate

Cat. No. 17-003 - A549 Cell Slide

RING1 and YY1 binding protein

Homo sapiens

Zheng L, Schickling O, Peter ME, et al. The death effector domain-associated factor (DEDAF) plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. 2001; 276:31945-52.

Garcia E, Marcos-Gutierrez C, del Mar Lorente M, et al. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 1999;18:3404-18.

DEDAF Antibody: AAP1, DEDAF, YEAF1, RING1 and YY1-binding protein, Apoptin-associating protein 1, APAP-1

ELISA, WB, IHC-P, IF

5802963

Liquid