Defactinib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM) .1 It is active in vivo (EC50 = 26nM) . FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
Unconjugated
White solid
-20°C
Beschrijving
Defactinib Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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