Dehydrofalcarinol
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Dehydrofalcarinol is a polyacetylene compound found in Desmanthodium guatemalense. Dehydrofalcarinol shows potent inhibitory activity against MDA-MB-231, MDA-MB-157, BT-549, HCC1806, MDA-MB-468 and MDA-MB-453 cells with IC50 values of 0.051, 0.059, 0.22, 0.3, 0.85 and 2.8 μM. Dehydrofalcarinol shows anticancer activity depending on 17β-hydroxysteroid dehydrogenase (17β-HSD) type 11. Dehydrofalcarinol can be used for the research of triple-negative breast cancer[1].
36150-08-0
12352211
17β-HSD
Metabolic Enzyme/Protease
Cancer
C=CCCCCC/C=C\CC#CC#C[C@H](O)C=C
C17H22O
242.36
[1]Grant CV, et al. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. J Nat Prod. 2020 Oct 23;83 (10) :3080-3092.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-180915/
Reference compound
No Development Reported
Beschrijving
Dehydrofalcarinol is a polyacetylene compound found in Desmanthodium guatemalense. Dehydrofalcarinol shows potent inhibitory activity against MDA-MB-231, MDA-MB
Specificaties
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