DELE Antilichaam

DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α , anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

9812

Q14154

NP_055588

Human, Rat

Unconjugated

Primary Antibodies

Apoptosis

DELE Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (71%)

DELE Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DELE antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

KIAA0141

Cat. No. 10-301 - Human Brain Tissue Slide

KIAA0141

Homo sapiens

Harada T, Iwai A, Miyazaki T. Identification of DELE, a novel DAP-binding protein which is crucial for death receptor-mediated apoptosis induction. Apoptosis 2010; 15:1247-55.

DELE Antibody: DELE, DELE, Death ligand signal enhancer

ELISA, WB, IF

217330656

Liquid