DEPTTOR Antilichaam

DEPTOR is an mTOR (mammalian target of rapamycin) -interacting protein whose expression is negatively regualted by mTOR complex 1 (mTORC1) and mTORC2 (1) . Loss of DEPTOR activates RP6SK1, Akt1, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR expression is low in most cancers, but is often elevated in multiple myelomas (1) . In respons to stimulation by mitogens, DEPTOR is rapidly phosphorylated leading to its ubiquitination and degradation, allowing mTOR to generate an auto-amplification loop to promotes its own full activation (2) .

64798

Q8TB45

NP_073620

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

DEPTOR antibody is affinity chromatography purified via peptide column.

Cat. No. 1404 - Mouse Liver Tissue Lysate

1 mg/mL

DEPTOR Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

DEPTOR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

DEPTOR antibody is human, mouse and rat reactive. At least three isoforms of DEPTOR are known to exist; this antibody will detect all three isoforms.

DEPTOR

DEP domain containing MTOR-interacting protein

Homo sapiens

Peterson TR, Laplante M, Thoreen CC, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for survival. Cell 2009; 137:873-6.

Duan S, Skaar JR, Kuchay S, et al. mTOR generates an auto-amplification loop by triggering the bTrCP- and CK1a-dependent degradation of DEPTOR. Mol. Cell 2011; 44:317-24.

DEPTOR Antibody: DEP.6, DEPDC6, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6

ELISA, WB, IHC-P

189571664

Liquid