Desethoxyquetiapine (dihydrochloride)

Desethoxy Quetiapine dihydrochloride (Compound 28) is an antagonist for dopamine D2 receptor with an IC50 of 1330 nM. Desethoxy Quetiapine dihydrochloride antagonises Apomorphine -induced climbing and swimming disruption in mouse models[1].

329218-14-6

12352005

Dopamine Receptor

GPCR/G Protein; Neuronal Signaling

Neurological Disease

OCCN(CC1)CCN1C2=NC3=CC=CC=C3SC4=CC=CC=C42.Cl.Cl

C19H23Cl2N3OS

412.38

[1]Warawa EJ, et al., Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel. J Med Chem. 2001 Feb 1;44 (3) :372-89.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W151617A/

Reference compound1

No Development Reported

D2 Receptor