(±) -Desisopropylpropranolol

(±) -Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[1][2][3][4].

20862-11-7

N-Desisopropylpropranolol

12352005

H315-H319-H320

Adrenergic Receptor; Drug Metabolite

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Cancer; Endocrinology; Neurological Disease; Cardiovascular Disease

C1=CC=C2C(=C1)C=CC=C2OCC(CN)O

C13H15NO2

217.26

P264-P280-P302+P352-P305+P351+P338-P362

[1]Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70 (5) :1575-84. |[2]Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69 (4) :669-73. |[3]Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. |[4]ZHAO L, et al. LC/MS/MS determination of propranolol and its metabolites 4-hydroxypropranolol and N-desisopropylpropranolol in rat plasma[J]. Chinese Journal of Pharmaceutical Analysis, 2005, 25 (10) : 1203-1206.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W192276/

Reference compound2

No Development Reported

β adrenergic receptor