Desmethylglyciteïne (standaard)

Desmethylglycitein (4',6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities. Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity[1]. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC) α, against solar UV (sUV) -induced matrix matrix metalloproteinase 1 (MMP1) [2]. Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes[3].

17817-31-1

12352005

CDK; PI3K; PKC

Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; TGF-beta/Smad

Cancer

O=C1C(C2=CC=C(O)C=C2)=COC3=CC(O)=C(O)C=C13

C15H10O5

270.24

[1]Lee DE, et al. 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. Carcinogenesis. 2011 Apr;32 (4) :629-35.|[2]Lim TG, et al. The daidzein metabolite, 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1. Int J Mol Sci. 2014 Nov 19;15 (11) :21419-32|[3]Seo SG, et al. A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N5072R/

Reference Standards