Desmin Antilichaam [10H7D2]

Desmin (DES), with 470-amino acid protein (about 52 kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.

1674

P17661

P17661

Human

Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3) .

10H7D2

Unconjugated

Primary Antibodies

Other

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

Desmin monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

DES

Desmin

Homo sapiens

Felix R. Shardonofsky, Yassemi Capetanaki, and Aladin M. Boriek. Am J Physiol Lung Cell Mol Physiol, May 2006; 290: L890 - L896.

Xupei Huang, Jian Li, Dalton Foster. Experimental Biology and Medicine, Dec 2002; 227: 1039.

CSM1, CSM2, LGMD2R

ELISA, WB, IHC

6686280