DFFB Antilichaam

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined.

1677

O76075

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 109-338 of human DFFB (NP_004393.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle

Affinity purification

A-549

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 39kDa

IgG

DFFB

K-562

SW620

Mouse spleen

Mouse thymus

DNA fragmentation factor subunit beta

Homo sapiens

CAD, CPAN, DFF-4DFF2, DFF4DNA fragmentation factor subunit beta, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), caspase-activated DNase, caspase-activated deoxyribonuclease, caspase-activated nuclease

WB, IHC

Liquid