DGM
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process in alveolar epithelial cells and slows the progression of pulmonary fibrosis in vivo by reducing lung inflammation, improving lung function, and decreasing extracellular matrix (ECM) remodeling. DGM can be used in research on idiopathic pulmonary fibrosis (IPF) and EMT-related diseases[1].
162401-62-9
12352005
H301
TGF-beta/Smad
Stem Cell/Wnt; TGF-beta/Smad
COVID-19-immunoregulation
Inflammation/Immunology
10mM
99.99
DMSO : 100 mg/mL (ultrasonic)
O=C(O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
C12H12F2O4
258.22
H301
[1]Sun T, et al. Inhibitory Effects of 3-Cyclopropylmethoxy-4- (difluoromethoxy) Benzoic Acid on TGF-β1-Induced Epithelial-Mesenchymal Transformation of In Vitro and Bleomycin-Induced Pulmonary Fibrosis In Vivo. Int J Mol Sci. 2023 Mar 24;24 (7) :6172.
Room Temperature
-20°C, 3 years; 4°C, 2 years (Powder)
http://file.medchemexpress.com/batch_PDF/HY-W005379/DGM-SDS-MedChemExpress.pdf
Natural Products
No Development Reported
Beschrijving
DGM is an inhibitor of the TGF-β1/Smad signaling pathway with significant antifibrotic effects. DGM inhibits the epithelial-mesenchymal transition (EMT) process
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