Diclofensine-d3 (hydrochloride)

Diclofensine-d3 hydrochloride is the deuterium labeled Diclofensine hydrochloride. Diclofensine hydrochloride (Ro-8-4650 hydrochloride) is a potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively.

1794780-41-8

12352005

Dopamine Transporter; Isotope-Labeled Compounds

Neuronal Signaling; Others

Neurological Disease

10 mM in DMSO

COC1=CC=C(C(C2)=C1)C(C3=CC(Cl)=C(C=C3)Cl)CN2C([2H])([2H])[2H].Cl

C17H15D3Cl3NO

361.71

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Hyttel J, et al. Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of dopamine, noradrenaline, and serotonin. J Neurochem. 1985 May;44 (5) :1615-22.|[3]Gasic S, et al. Effect of diclofensine, a novel antidepressant, on peripheral adrenergic function. Clin Pharmacol Ther. 1986 May;39 (5) :582-5.|[4]Di Renzo G, et al. Pure uptake blockers of dopamine can reduce prolactin secretion: studies with diclofensine. Life Sci. 1988;42 (21) :2161-9.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18610S/

Isotope-Labeled Compounds

No Development Reported