Dicoumarol-d8

Dicoumarol-d8 (Dicumarol-d8) is the deuterium labeled Dicoumarol. Dicoumarol is an inhibitor of both NAD (P) H:quinone oxidoreductase 1 (NQO1) and PDK1 with IC50s of 0.37 and 19.42 μM, respectively.

2469035-18-3

Dicumarol-d8

12352005

Isotope-Labeled Compounds; PDHK

Metabolic Enzyme/Protease; Others

Cancer

10 mM in DMSO

O=C1OC2=C(C(O)=C1CC3=C(O)C4=C(C([2H])=C([2H])C([2H])=C4[2H])OC3=O)C([2H])=C([2H])C([2H])=C2[2H]

C19H4D8O6

344.34

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Bian J, et al. Affinity-based small fluorescent probe for NAD (P) H:quinone oxidoreductase 1 (NQO1) . Design, synthesis and pharmacological evaluation. Eur J Med Chem. 2017 Feb 15;127:828-839.|[3]Zhang W, et al. Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells. PLoS One. 2017 Jun 15;12 (6) :e0179672.|[4]Fiorillo M, et al. Mitochondrial "power" drives tamoxifen resistance: NQO1 and GCLC are new therapeutic targets in breast cancer. Oncotarget. 2017 Mar 2;8 (12) :20309-20327.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N0645S/

Isotope-Labeled Compounds

No Development Reported