Difenidol-d10 (hydrochloride)

Diphenidol-d10 (hydrochloride) (Difenidol hydrochloride-d10) is deuterium labeled Diphenidol (hydrochloride) . Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea[1][2][3][4][5].

Difenidol hydrochloride-d10

12352005

Isotope-Labeled Compounds; mAChR; Sodium Channel

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Neuroscience-Neuromodulation

Neurological Disease

OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H].[H]Cl

C21H18D10ClNO

355.97

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64 (3) :739-44.|[3]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58 (7) :1147-52.|[4]Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58 (7) :1147-52.|[5]Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.|[6]Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17 (9) :589-90.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-A0082S/

Isotope-Labeled Compounds

No Development Reported