Dihydrohonokiol B

Dihydrohonokiol B (Dihydrohonokiol) is an anxiolytic agent. Dihydrohonokiol B can reduce the neurotoxicity induced by amyloid β protein by stimulating the GABAC receptor. Dihydrohonokiol B can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1][2].

219565-74-9

Dihydrohonokiol

12352005

GABA Receptor

Membrane Transporter/Ion Channel; Neuronal Signaling

Neurological Disease

99.29

DMSO : 50 mg/mL (ultrasonic)

OC1=CC=C(CCC)C=C1C2=CC(CC=C)=C(O)C=C2

C18H20O2

268.35

[1]Esumi T, et al. Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan. Bioorg Med Chem Lett. 2004 May 17;14 (10) :2621-5.|[2]Liu B, et al. Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons. Neurosci Lett. 2005 Aug 12-19;384 (1-2) :44-7.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-N13742/Dihydrohonokiol-B-SDS-MedChemExpress.pdf

Natural Products

No Development Reported