Dihydrosamide

Dihydrosamidin is a coumarin component isolated from the fruits of ammi visnaga. Dihydrosamidin promotes neuroplasticity, modulates glycolysis and oxidative phosphorylation and enhances antioxidant defences. Dihydrosamidin inhibits triacylglycerol accumulation in 3T3-L1 preadipocytes. Dihydrosamidin can be used for neuroprotective, anti-obesity study[1][2][3].

6005-18-1

Dimidin

12352005

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolic Disease; Neurological Disease

CC(O[C@@H]1C2=C(OC(C)([C@@H]1OC(CC(C)C)=O)C)C=CC(C=C3)=C2OC3=O)=O

C21H24O7

388.41

[1]Winderl B, et al. Fast and improved separation of major coumarins in Ammi visnaga (L.) Lam. by supercritical fluid chromatography. J Sep Sci. 2016 Oct;39 (20) :4042-4048.|[2]Toropova AA, et al. Dihydrosamidin: the basic khellactone ester derived from Phlojodicarpus komarovii and its impact on neurotrophic factors, energy and antioxidant metabolism after rat cerebral ischemia-reperfusion injury. Nat Prod Res. 2024 Nov 27:1-6.|[3]Olennikov DN, et al. Khellactone Derivatives and Other Phenolics of Phlojodicarpus sibiricus (Apiaceae) : HPLC-DAD-ESI-QQQ-MS/MS and HPLC-UV Profile, and Antiobesity Potential of Dihydrosamidin. Molecules. 2019 Jun 19;24 (12) :2286.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15448/

Natural Products

No Development Reported