Dimethyl-UHRF1-K385 pAb

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

29128

Q96T88

Human, Mouse

A synthetic monomethylated peptide around K385 of human UHRF1 (NP_001041666.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cell Cycle

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Methylated

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

UHRF1 K385me2

Ubiquitin-like with PHD and ring finger domains 1

Homo sapiens

UHRF1, ubiquitin-like, containing PHD and RING finger domains, 1, Np95, ICBP90, FLJ21925, transcription factor ICBP90, RNF106, MGC138707, RING finger protein 106, inverted CCAAT box-binding protein of 90 kDa, nuclear zinc finger protein Np95, transcriptio

IHC, IF

Liquid